Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
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چکیده
منابع مشابه
Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
The interleukin (IL)-12-type cytokines IL-12 and IL-23 are involved in T-helper (Th) 1 and Th17 immunity, respectively. They share the IL-12 receptor β1 (IL-12Rβ1) as one component of their receptor signaling complexes, with IL-12Rβ2 as second receptor for IL-12 and IL-23R for IL-23 signal transduction. Stimulation with IL-12 and IL-23 results in activation of receptor-associated Janus kinases ...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2016
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e14-12-1645